Hypervitaminosis A

HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS

In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...

Adult Hypervitaminosis D-A Case Series

Prolonged hypervitaminosis D can result in calcium deposition in the soft tissues (especially the kidneys and heart), changes in the central nervous system & in severe cases, death. Patients and clinicians considering supplementation above currently recommended levels should be made aware of the possible toxicities of treatment with vitamin D, and baseline calcium and parathyroid hormone and vi...

Cxix. Hypervitaminosis and Vitamin

THE object of this paper is to record a continuation of experiments in which the existence is demonstrated of a "balance" between the vitamin B complex on the one hand and vitamins A and D of cod-liver oil on the other. Only two previous communications bearing directly on this subject have appeared in the literature, so far as we are aware. In the first place, Hopkins [1923] mentioned that he h...

Hypervitaminosis A accompanying advanced chronic renal failure.

Hypervitaminosis A: side-effects of retinoids.

Breitman, T. R., Selonick. S. E. & Collins, S. J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 2936-2940 Dawson, M. I., Hobbs, P. D., Derdzinski, K., Chan, R. L.-S., Gruber, J., Chao, W., Smith, S., Thies, R. W. & Schiff, L. J. (1984) J . Med. Chem. 27, 15161531 Frickel, F. (1984) in The Retinoih (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), vol. I , pp. 7-145 Academic Press, Orlando, FL F...